Aesthetic Services

Both Restylane® and Juvéderm™ are both facial dermal fillers and both are made up of naturally occurring hyaluronic acid (HA) and come in an injectable syringe. Both are (HA) injectible fillers most commonly used for lip enhancement and facial contouring.

These products are safe and natural cosmetic dermal fillers that restore fullness to the skin to correct moderate to severe facial wrinkles and folds, such as nasolabial folds. Both provide volumizing and correction to facial wrinkles and folds. Therefore, they are indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds such as the more common nasolabial folds (smile lines), oral commissures (marionette lines), and perioral lines (smoker’s lines). Both are relatively safe, and offer minimal recovery or downtime. Side effects were usually mild to moderate lasting 2-7 days or less and included temporary injection site reactions like redness, pain, firmness, swelling and bumps. Further, the risks of allergic reactions are minimal. Studies with Juvéderm™ showed no increased risk of hyperpigmentation or hypertrophic scarring in patients of color.

One of the differences between the two is that Juvéderm™ has the highest concentration of cross-linked HA (24 mg/mL). This means that it resist degradation and therefore last longer. Juvéderm™ offers clinically-proven persistence up to 6 months or longer whereas Restylane® normally last between 3 to 6 months.

Another difference is that Juve’Derm offers 2 lines of products, whereas Restylane offers only one. The two versions of Juvéderm™ are Juvéderm™ Ultra and Juvéderm™ Ultra Plus. The Juvéderm™ Ultra is approximately 30% HA and is more commonly used to add volume to the vermillion border (between the lips and skin border) and to add volume to the lips. This can afford a fuller look without appearing too “Hollywood” or as if “you had something done”. Juvéderm™ Ultra Plus is a more robust formulation than Juve’Derm Ultra and comprised of approximately 60% HA and is used for volumizing and correcting deeper folds and wrinkles such as the nasolabial folds (smile lines) and oral commissures (marionette lines). The two versions of Juvéderm™ offers more versatility in contouring and volumizing facial wrinkles and folds.

A third difference relates to the size of the particle of the injected material. Juvéderm™ boast a “next-generation” hyaluronic acid dermal filler that is the only injectable gel that has a smooth consistency gel; other existing hyaluronic acid dermal fillers are made of granular consistency gels.* This smooth consistency gel affords an enhanced performance in how the material is injected and how it is received and interacted by your body. A smoother consistency means that there will be less irritation and therefore, less post injection inflammation. It also means that Juvéderm™ filler should provide a smooth consistency gel that flows easily into the skin and creates a natural look and feel.

JUVÉDERM™ RESTYLANE†

*Dry test, extrusion of a small amount (˜.025 mL) of JUVÉDERM™ injectable gel and RESTYLANE onto a glass surface at 9x magnification. †RESTYLANE is a registered trademark of Q-Med AB.

Finally, many patients overwhelmingly preferred Juvéderm™ products over study control. In fact, 78%-88% of patients preferred Juvéderm™ injectable gel at 6 months post-treatment.

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